Pet Toxicity Directory
Medications Toxicity Guide for Dogs and Cats
Review human medications and supplements that are dangerous for pets. Browse 58 items with safety status, symptoms to watch for, and emergency guidance.
5-Fluorouracil (Cancer Cream)
DangerExtremely toxic. Severe GI signs, neurotoxicity, bone marrow suppression. Fatal from licking treated skin.
View details5-Fluorouracil Cream
DangerEXTREMELY toxic to dogs even in trace amounts. Chewing tube can be rapidly fatal.
View detailsAcetaminophen (Tylenol)
DangerExtremely toxic to cats (one tablet can be fatal). Causes liver damage and red blood cell damage.
View detailsADHD Medications
DangerStimulants. Extremely dangerous. Even small amounts fatal.
View detailsADHD Medications (Adderall,Ritalin)
DangerStimulants cause severe cardiovascular and neurological signs. Even small doses fatal.
View detailsAlbuterol Inhaler
DangerPunctured inhaler releases massive dose causing severe cardiac effects and potassium disturbances.
View detailsAntidepressants (SSRI/SNRI)
DangerCause serotonin syndrome in pets. Severe neurological, cardiovascular, thermoregulatory effects.
View detailsAntidepressants (SSRIs)
DangerCan cause serotonin syndrome. Even one pill is serious.
View detailsAntihistamines (Benadryl)
DangerAntihistamines can cause serious side effects in pets. Cats are especially sensitive.
View detailsAspirin
DangerStomach ulcers and kidney damage. Cats especially sensitive.
View detailsBenzodiazepines (Xanax,Valium)
DangerCause severe CNS depression. Paradoxically can cause agitation.
View detailsBeta Blockers
DangerCause severe drop in heart rate and blood pressure. Single tablet can be life-threatening.
View detailsBlood Pressure Medications
DangerCan cause dangerous drops in blood pressure and heart rate.
View detailsBlood Pressure Medications
DangerCan cause severe hypotension, kidney failure, electrolyte imbalances.
View detailsBlood Thinners (Warfarin)
DangerBlood thinners prevent clotting. Even small overdoses cause severe bleeding.
View detailsCaffeine Pills
DangerHighly concentrated caffeine. A single pill can be lethal to small dogs. Causes severe cardiac and CNS stimulation.
View detailsCalcium Channel Blockers
DangerCause severe hypotension and bradycardia. Small doses life-threatening for small pets.
View detailsChewable Vitamins (human)
DangerOften contain xylitol for sweetening. Iron-containing add iron toxicity.
View detailsClonidine
DangerCauses severe hypotension and sedation. Very potent - small doses dangerous.
View detailsCough Syrup (Dextromethorphan)
DangerCough syrups often contain dextromethorphan and/or xylitol. Both dangerous.
View detailsDecongestant Nasal Spray
DangerImidazolines cause severe vasoconstriction, hypertension, and bradycardia. Tiny amounts dangerous.
View detailsDiabetes Medications
DangerCause life-threatening hypoglycemia.
View detailsDigoxin / Digitalis
DangerVery narrow therapeutic window. Overdose causes severe cardiac arrhythmias.
View detailsDog Flea Meds (Toxic to Cats)
DangerPermethrin flea treatments for dogs HIGHLY TOXIC to cats.
View detailsIbuprofen (Advil, Motrin)
DangerIbuprofen is highly toxic to pets. Even one pill can cause serious kidney damage or stomach ulcers.
View detailsInsulin
DangerInsulin overdose causes severe hypoglycemia. Life-threatening emergency.
View detailsIron Supplements
DangerIron toxicity causing liver damage and metabolic acidosis.
View detailsIron Supplements
DangerCause severe GI corrosion and cellular toxicity. Can be fatal.
View detailsLithium
DangerNarrow therapeutic index. Overdose causes severe neurological and renal toxicity.
View detailsMetformin
DangerCauses severe hypoglycemia and lactic acidosis. Especially dangerous in cats.
View detailsMinoxidil (Rogaine)
DangerVery toxic especially to cats. Even small ingestions cause severe hypotension and heart failure.
View detailsNaproxen (Aleve)
DangerMore toxic to dogs than ibuprofen. Severe GI ulceration, kidney damage, neurological effects.
View detailsOpioid Pain Medications
DangerCause severe sedation, respiratory depression. Can be fatal.
View detailsOral Decongestants
DangerStimulants causing hypertension, tachycardia, agitation, tremors, hyperthermia.
View detailsPseudoephedrine (Sudafed)
DangerDecongestants cause severe stimulation - hyperactivity, tremors, seizures, tachycardia.
View detailsPsoriasis Creams
DangerVitamin D analogs cause severe hypercalcemia and kidney failure. Highly toxic in small amounts.
View detailsSleeping Pills (Benzodiazepines)
DangerSevere sedation and incoordination.
View detailsSuboxone / Buprenorphine
DangerPotent opioid. Causes severe respiratory depression and can be fatal in small pets.
View detailsThyroid Medication
DangerThyroid hormone overdose causes severe metabolic and cardiac symptoms.
View detailsTopical Estrogen Cream
DangerTransdermal hormone creams absorbed through pet skin contact. Can cause bone marrow suppression and feminization.
View detailsTopical NSAIDs (Voltaren)
DangerExtremely toxic to cats - licking small amount can cause fatal kidney failure.
View detailsVitamin D (Cholecalciferol) Overdose
DangerVitamin D overdose causes dangerous hypercalcemia leading to kidney failure and soft tissue calcification.
View detailsVitamin D Supplements
DangerOverdose causes dangerous calcium levels. Kidney failure.
View detailsAmbien / Zolpidem
ToxicCauses sedation, ataxia, and paradoxical excitation. Cats may become agitated.
View detailsDiet Pills / Weight Loss Meds
ToxicMay contain stimulants (caffeine, ephedra) causing cardiac and neurological toxicity.
View detailsEffexor / Venlafaxine
ToxicSNRI causing serotonin syndrome: agitation, tremors, elevated HR. Cats especially sensitive.
View detailsMuscle Relaxants
ToxicCause profound sedation and weakness. Baclofen especially dangerous: can cause coma.
View detailsZinc Oxide (Diaper Cream)
ToxicCauses GI irritation and in large amounts zinc toxicity leading to hemolytic anemia.
View detailsBirth Control Pills
CautionLow-dose modern pills rarely acutely toxic. Mild GI upset possible.
View detailsGabapentin
CautionPrescribed to pets for pain/anxiety. Overdose causes sedation and ataxia. Generally safe.
View detailsLisinopril / ACE Inhibitors
CautionPrescribed to pets for heart/kidney disease. Overdose causes low BP but rarely life-threatening.
View detailsProton Pump Inhibitors
CautionSometimes prescribed for pets. Overdose causes GI upset. Generally safe.
View detailsProzac / Fluoxetine
CautionPrescribed to pets. Overdose causes serotonin syndrome: agitation, tremors, elevated HR.
View detailsTopical Steroid Creams
CautionGI upset if licked. Some contain NSAIDs/steroids.
View detailsTopical Steroid Creams
CautionSmall ingestion causes mild GI upset. Chronic ingestion can cause Cushingoid symptoms.
View detailsTramadol
CautionPrescribed to pets for pain. Overdose causes sedation, agitation, tremors, possible seizures.
View detailsTrazodone
CautionCommonly prescribed to pets for anxiety/sedation. Overdose causes excessive sedation and ataxia.
View detailsXanax / Alprazolam
CautionPrescribed to pets for anxiety. Overdose causes profound sedation. Large doses: respiratory depression.
View details