Toxicity Checker/Medications

Pet Toxicity Directory

Medications Toxicity Guide for Dogs and Cats

Review human medications and supplements that are dangerous for pets. Browse 58 items with safety status, symptoms to watch for, and emergency guidance.

58 total items48 toxic or dangerous

How to Use This Medications Safety List

Step 1

Start with risk level

Danger and toxic entries need the fastest attention, especially when the amount is unknown.

Step 2

Open the item page

Each detail page gives dog and cat answers, symptoms, action steps, sources, and related checks.

Step 3

Escalate symptoms

If vomiting, tremors, weakness, breathing trouble, or collapse appears, contact a veterinary professional.

Common Medications Toxicity Questions

Which medications are most dangerous for dogs and cats?

Start with 5-Fluorouracil (Cancer Cream), 5-Fluorouracil Cream, Acetaminophen (Tylenol), ADHD Medications, ADHD Medications (Adderall,Ritalin). This category currently includes 48 toxic or dangerous entries, so open the item page for symptoms and next steps.

What symptoms can medications poisoning cause?

Watch for vomiting, diarrhea, drooling, coughing, tremors, weakness, collapse, seizures, pale gums, trouble breathing, or unusual behavior after exposure.

When should I call a veterinarian or poison-control hotline?

Call right away if the item is marked toxic or danger, the amount is unknown, your pet is small, symptoms appear, or the exposure involves medication, concentrated chemicals, or a known emergency toxin.

What should I do if my pet ate human medication?

Treat human medication exposure as urgent. Keep the bottle or packaging, estimate the amount and time, and call your veterinarian or a pet poison-control hotline before symptoms progress.

5-Fluorouracil (Cancer Cream)

Danger

Extremely toxic. Severe GI signs, neurotoxicity, bone marrow suppression. Fatal from licking treated skin.

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5-Fluorouracil Cream

Danger

EXTREMELY toxic to dogs even in trace amounts. Chewing tube can be rapidly fatal.

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Acetaminophen (Tylenol)

Danger

Extremely toxic to cats (one tablet can be fatal). Causes liver damage and red blood cell damage.

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ADHD Medications

Danger

Stimulants. Extremely dangerous. Even small amounts fatal.

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ADHD Medications (Adderall,Ritalin)

Danger

Stimulants cause severe cardiovascular and neurological signs. Even small doses fatal.

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Albuterol Inhaler

Danger

Punctured inhaler releases massive dose causing severe cardiac effects and potassium disturbances.

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Antidepressants (SSRI/SNRI)

Danger

Cause serotonin syndrome in pets. Severe neurological, cardiovascular, thermoregulatory effects.

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Antidepressants (SSRIs)

Danger

Can cause serotonin syndrome. Even one pill is serious.

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Antihistamines (Benadryl)

Danger

Antihistamines can cause serious side effects in pets. Cats are especially sensitive.

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Aspirin

Danger

Stomach ulcers and kidney damage. Cats especially sensitive.

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Benzodiazepines (Xanax,Valium)

Danger

Cause severe CNS depression. Paradoxically can cause agitation.

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Beta Blockers

Danger

Cause severe drop in heart rate and blood pressure. Single tablet can be life-threatening.

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Blood Pressure Medications

Danger

Can cause dangerous drops in blood pressure and heart rate.

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Blood Pressure Medications

Danger

Can cause severe hypotension, kidney failure, electrolyte imbalances.

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Blood Thinners (Warfarin)

Danger

Blood thinners prevent clotting. Even small overdoses cause severe bleeding.

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Caffeine Pills

Danger

Highly concentrated caffeine. A single pill can be lethal to small dogs. Causes severe cardiac and CNS stimulation.

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Calcium Channel Blockers

Danger

Cause severe hypotension and bradycardia. Small doses life-threatening for small pets.

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Chewable Vitamins (human)

Danger

Often contain xylitol for sweetening. Iron-containing add iron toxicity.

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Clonidine

Danger

Causes severe hypotension and sedation. Very potent - small doses dangerous.

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Cough Syrup (Dextromethorphan)

Danger

Cough syrups often contain dextromethorphan and/or xylitol. Both dangerous.

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Decongestant Nasal Spray

Danger

Imidazolines cause severe vasoconstriction, hypertension, and bradycardia. Tiny amounts dangerous.

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Diabetes Medications

Danger

Cause life-threatening hypoglycemia.

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Digoxin / Digitalis

Danger

Very narrow therapeutic window. Overdose causes severe cardiac arrhythmias.

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Dog Flea Meds (Toxic to Cats)

Danger

Permethrin flea treatments for dogs HIGHLY TOXIC to cats.

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Ibuprofen (Advil, Motrin)

Danger

Ibuprofen is highly toxic to pets. Even one pill can cause serious kidney damage or stomach ulcers.

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Insulin

Danger

Insulin overdose causes severe hypoglycemia. Life-threatening emergency.

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Iron Supplements

Danger

Iron toxicity causing liver damage and metabolic acidosis.

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Iron Supplements

Danger

Cause severe GI corrosion and cellular toxicity. Can be fatal.

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Lithium

Danger

Narrow therapeutic index. Overdose causes severe neurological and renal toxicity.

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Metformin

Danger

Causes severe hypoglycemia and lactic acidosis. Especially dangerous in cats.

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Minoxidil (Rogaine)

Danger

Very toxic especially to cats. Even small ingestions cause severe hypotension and heart failure.

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Naproxen (Aleve)

Danger

More toxic to dogs than ibuprofen. Severe GI ulceration, kidney damage, neurological effects.

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Opioid Pain Medications

Danger

Cause severe sedation, respiratory depression. Can be fatal.

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Oral Decongestants

Danger

Stimulants causing hypertension, tachycardia, agitation, tremors, hyperthermia.

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Pseudoephedrine (Sudafed)

Danger

Decongestants cause severe stimulation - hyperactivity, tremors, seizures, tachycardia.

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Psoriasis Creams

Danger

Vitamin D analogs cause severe hypercalcemia and kidney failure. Highly toxic in small amounts.

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Sleeping Pills (Benzodiazepines)

Danger

Severe sedation and incoordination.

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Suboxone / Buprenorphine

Danger

Potent opioid. Causes severe respiratory depression and can be fatal in small pets.

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Thyroid Medication

Danger

Thyroid hormone overdose causes severe metabolic and cardiac symptoms.

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Topical Estrogen Cream

Danger

Transdermal hormone creams absorbed through pet skin contact. Can cause bone marrow suppression and feminization.

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Topical NSAIDs (Voltaren)

Danger

Extremely toxic to cats - licking small amount can cause fatal kidney failure.

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Vitamin D (Cholecalciferol) Overdose

Danger

Vitamin D overdose causes dangerous hypercalcemia leading to kidney failure and soft tissue calcification.

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Vitamin D Supplements

Danger

Overdose causes dangerous calcium levels. Kidney failure.

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Ambien / Zolpidem

Toxic

Causes sedation, ataxia, and paradoxical excitation. Cats may become agitated.

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Diet Pills / Weight Loss Meds

Toxic

May contain stimulants (caffeine, ephedra) causing cardiac and neurological toxicity.

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Effexor / Venlafaxine

Toxic

SNRI causing serotonin syndrome: agitation, tremors, elevated HR. Cats especially sensitive.

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Muscle Relaxants

Toxic

Cause profound sedation and weakness. Baclofen especially dangerous: can cause coma.

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Zinc Oxide (Diaper Cream)

Toxic

Causes GI irritation and in large amounts zinc toxicity leading to hemolytic anemia.

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Birth Control Pills

Caution

Low-dose modern pills rarely acutely toxic. Mild GI upset possible.

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Gabapentin

Caution

Prescribed to pets for pain/anxiety. Overdose causes sedation and ataxia. Generally safe.

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Lisinopril / ACE Inhibitors

Caution

Prescribed to pets for heart/kidney disease. Overdose causes low BP but rarely life-threatening.

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Proton Pump Inhibitors

Caution

Sometimes prescribed for pets. Overdose causes GI upset. Generally safe.

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Prozac / Fluoxetine

Caution

Prescribed to pets. Overdose causes serotonin syndrome: agitation, tremors, elevated HR.

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Topical Steroid Creams

Caution

GI upset if licked. Some contain NSAIDs/steroids.

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Topical Steroid Creams

Caution

Small ingestion causes mild GI upset. Chronic ingestion can cause Cushingoid symptoms.

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Tramadol

Caution

Prescribed to pets for pain. Overdose causes sedation, agitation, tremors, possible seizures.

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Trazodone

Caution

Commonly prescribed to pets for anxiety/sedation. Overdose causes excessive sedation and ataxia.

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Xanax / Alprazolam

Caution

Prescribed to pets for anxiety. Overdose causes profound sedation. Large doses: respiratory depression.

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